Year: 2018 | Month: June | Volume 6 | Issue 1
Multiple Sequence Alignment and Phylogenetic Tree Construction of Viral Protein 2 of Bluetongue virus
DOI:10.30954/2319-5169.01.2018.6
Abstract:
Bluetongue is a non contagious disease of animals and spread by the biting midges. Bluetongue disease is mild in goats and severe in sheep as sheep is the primary host of bluetongue virus. There are several clinical symptoms of Bluetongue disease have been found in ruminants like fever, viraemia, sore muzzle, facial oedema, hyperaemia and congestion, erosion of mucous memberane, haemorrhages, vascular permeability. The bluetongue virus is hypervariable in nature therefore there are 24 serotypes of bluetongue virus are well recognised with three newly proposed serotypes BTV 25 from Switzerland and BTV 26 from Quwait and BTV 27 from France. Therefore, there are 27 different serotypes of BTV have been identified according to the specificity of interactions between neutralizing antibodies and the virus outer capsid, the VP2 protein. Bluetongue has a serious economic impact on dairy and wool industry mainly due to high morbidity, mortality and mandatory trade barrier on the movement of BT infected livestock and germplasm. Bioinformatical tools like Clustal X and Clustal Omega are promising and helpful in the construction of phylogenetic tree to check the evolutionary relation among all 24 serotypes of BTV and alignment of the many sequences through Multiple sequence Alignment.
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